Cost function – Beacon at Bangsar Wed, 29 Jun 2022 11:14:00 +0000 en-US hourly 1 Cost function – Beacon at Bangsar 32 32 Positive data from the MAD phase I clinical study with the Alzheimer’s project of AlzeCure NeuroRestore ACD856 Wed, 29 Jun 2022 11:14:00 +0000

STOCKHOLM, June 29, 2022 /PRNewswire/ — AlzeCure Pharma AB (publ) (FN STO: ALZCUR)a pharmaceutical company developing a broad portfolio of small molecule drug candidates for diseases affecting the central nervous system, with projects in Alzheimer’s disease and pain, announced today that the company has completed the phase I clinical study (multiple ascending doses, MAD) with repeated administration of the drug candidate ACD856, with a focus on Alzheimer’s disease.

The data shows that ACD856, the lead drug candidate of the company’s NeuroRestore platform, exhibits good tolerability and safety. Furthermore, the results demonstrate that the substance has appropriate pharmacokinetic properties with rapid absorption in the body as well as relevant and dose-dependent exposure in the CNS.

The Phase I MAD study is AlzeCure’s third clinical study with ACD856, the company’s lead drug candidate in the NeuroRestore platform. The substance is being developed as a symptom relief treatment for disease states where cognitive ability is impaired, for example in Alzheimer’s disease. The main objective of the study was to assess the tolerance, safety and pharmacokinetics of the drug candidate after repeated administration.

“We are very pleased that ACD856 has a very good profile for further clinical development,” said John Sandin, CSO at AlzeCure Pharma. “With its potential to improve memory function in various diseases, ACD856 may play an important role in treating indications where these key functions are impaired, such as Alzheimer’s disease, sleep apnea, traumatic brain injury and Parkinson’s disease.”

The company began the study in September 2021 and now presents as planned the results of this clinical study with ACD856. Preparations are underway to launch new clinical trials. These upcoming studies focus on evaluating signals of early effects in humans.

“The results of the NeuroRestore ACD856 candidate follow previous positive clinical results with the substance, and we now look forward to continued clinical studies,” said Martin Jönsson, CEO of AlzeCure. “I also see this data will stimulate potential partnerships and licensing discussions and increase interest in the NeuroRestore platform.”

For more information please contact:

Martin Jonsson, CEO
Tel: +46 (0)70-786 94 43
E-mail: [email protected]

This is information that AlzeCure Pharma AB is required to make public under the EU Market Abuse Regulation. The information has been submitted for publication, through the agency of the contact person above, to 1:00 p.m. CEST on June 29, 2022.

About AlzeCure Pharma AB (publ)

AlzéCure® is a Swedish pharmaceutical company that develops innovative new small molecule drug therapies for the treatment of serious diseases and conditions that affect the central nervous system, such as Alzheimer’s disease and pain – indications for which Currently available treatments are very limited. The company is listed on the Nasdaq First North Premier Growth Market and is developing multiple parallel drug candidates based on three research platforms: NeuroRestore®Alzstatin® and Painless.

NeuroRestore consists of two symptomatic drug candidates whose unique mechanism of action enables multiple indications, including Alzheimer’s disease, as well as cognitive disorders associated with traumatic brain injury, sleep apnea and Parkinsons. The Alzstatin platform focuses on the development of disease-modifying and preventive drug candidates for the early treatment of Alzheimer’s disease and includes two drug candidates.

Painless is the Company’s pain research platform and contains two projects: ACD440, which is a drug candidate in clinical development for the treatment of neuropathic pain, and TrkA-NAM, which targets other types of severe pain in conditions such as osteoarthritis. AlzeCure aims to pursue its own projects through preclinical research and development to an early clinical phase and continuously works on commercial development to find suitable solutions for licensing agreements with other pharmaceutical companies.

FNCA Sweden AB, +46(0)8 528 00 399 [email protected], is the company’s certified advisor. For more information, please visit

About NeuroRestore

NeuroRestore is a platform of symptom-relieving drug candidates for disease states in which cognitive abilities are impaired, eg Alzheimer’s disease, sleep apnea, traumatic brain injury and Parkinson’s disease. NeuroRestore stimulates several important signaling pathways in the brain, which, among other things, leads to improved cognition. In preclinical studies with NeuroRestore, we were able to show that our drug candidates improve communication between nerve cells and improve cognitive abilities. NeuroRestore stimulates specific central nervous system signaling pathways called neurotrophins, the best known being NGF (Nerve Growth Factor) and BDNF (Brain Derived Neurotrophic Factor). NGF and BDNF levels are disrupted in several disease states and signaling is reduced. The impaired function impairs communication between synapses, i.e. the contact surfaces of nerve endings, as well as the possibility of nerve cell survival, giving rise to cognitive impairment. Neurotrophins play a crucial role for nerve cell function, and impaired BDNF function has a strong genetic link with impaired cognitive ability in several different diseases, such as Alzheimer’s disease, Parkinson’s disease, brain injury trauma and sleep disorders. There is also a link between BDNF signaling and depression, which has grown even stronger in recent years.

About Alzheimer’s Disease

Alzheimer’s disease is the most common form of dementia, affecting approximately 50 million people worldwide. Alzheimer’s disease is a fatal disease that also has a significant impact on loved ones and society. Today, preventive and disease-modifying treatments are lacking. The main risk factors for developing Alzheimer’s disease are age and genetic causes. Although the disease can begin between the ages of 40 and 65, it is more common after the age of 65. Significant investments in Alzheimer’s disease research are being made due to the large unmet medical need and high cost of this disease to health care and society. The total global cost of dementia-related illnesses is estimated at approximately 1 trillion dollars. Given the lack of effective symptomatic treatments and disease-modifying treatments, the need for new effective therapies is acute. The few approved drugs on the market today have only limited symptomatic effect and may produce dose-limiting side effects. Modifying therapy for Alzheimer’s disease is estimated to reach more than $15 billion in annual sales. In Swedenabout 100,000 people suffer from Alzheimer’s disease with a health cost of about 63 billion Swedish crowns annually, which is more than for cancer and cardiovascular diseases combined.

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SOURCEAlzeCure Pharma AB

Best Bed Tray | FOX31 Denver Sun, 26 Jun 2022 03:58:42 +0000

Which bed tray is the best?

A bed tray often conjures up images of bringing someone breakfast in bed on a special day, but a bed tray can have a place in everyday life. Bed trays come in handy when you’re feeling down, injured, or just want to relax in comfort.

A bed tray should be sturdy to avoid unnecessary spills and work to keep everything organized while you’re lying in bed. Bed trays are perfect for holding TV remotes, books, pen and paper, glasses and other small items. You can also use a bed tray to hold a laptop, tablet, or book at a comfortable reading angle while you’re in bed.

If you’re looking for a versatile bed tray, our top pick is the SONGMICS Bamboo Bed Tray, for its aesthetic design and ventilation holes.

What to know before buying a bed tray


Stability is a big consideration. You don’t want anything on the tray flying through your bed and potentially tipping over if a leg collapses. The ideal bed tray has legs that lock into place with a sturdy locking mechanism if they are collapsible.

Finding the right size bed tray is important. If it’s too big, it can be bulky and difficult to use. Determining the best size for your bed tray needs is key. Decide what the bed tray will most often contain to determine the best bed tray size.


Bed trays are not exclusively intended for use in bed. You can use one while sitting on the couch, on the floor, or even while traveling. Lighter weight correlates with better portability.

What to Look for in a Quality Bed Tray

Fold-down top

A drop-down roof is a useful feature. The recline feature may allow a person with a limited range of motion to make more use of the bed tray. This allows books or tablets to be visible when the user is unable to fully sit down or move their body. Flip tops can be useful for everyone and are an optional feature on a bed tray.


Whether it’s a built-in cup holder or a small drawer under the bed tray, storage can be a necessity or a nice extra feature. Small drawers are mostly equipped to hold things like a pen, a small pad of paper, and maybe a charger cord. A cup holder is great for someone who uses electronics on the bed tray because it will keep liquids from spilling out.


If the bed tray has legs that you can’t fold, it’s harder to find a place to store it. Legs that can fold up or down make the bed tray more functional when in use, depending on the position of the person using the bed tray.


A bed tray can be made from wood, metal, plastic, or a combination of any of these materials. The composition of the bed tray will determine the cost of the tray.

How much you can expect to spend on a bed tray

Bed trays range from $20 to $60, depending on material and features. The more features, the higher the cost can be. Most bed trays cost around $30, making them an affordable way to incorporate better ergonomics into your life.

Bed Tray FAQ

Does a bed tray need ventilation holes to keep your laptop cool?

A. Ventilation holes help but aren’t necessary to keep most laptops cool enough to run.

How do bed trays hold up to spills?

A. Depending on the finish of the bed tray, it can withstand being knocked over occasionally. Use a damp cloth to wipe it down and use a dry cloth to remove any residual moisture to keep your bed tray in good condition.

What is the best bed tray to buy?

Upper bed tray

SONGMICS bamboo bed tray

What do you want to know: This lightweight tray with a tilting top and ventilation holes is perfect for holding laptops, books and more.

What you will love: Ventilation holes improve airflow for a laptop.

What you should consider: Small objects can fall through the ventilation holes.

Or buy: Sold by Amazon

Upper bed tray for money

Winsome Wooden Breakfast Bed Tray

Winsome Wooden Breakfast Bed Tray

What do you want to know: This no-frills bed tray has foldable legs, a wide lip to keep things from falling off the edges, and a simple yet pleasing design.

What you will love: It’s one of the cheapest bed trays available, but it’s sturdy.

What you should consider: The lip around the perimeter of the tray may limit the size of items you can place on it.

Or buy: Sold by Amazon

Worth checking out

Extra-wide adjustable laptop stand for bed

SAIJI Adjustable Laptop Stand for Bed

What do you want to know: This space-looking bed tray has all the bells and whistles, like a small drawer, a tilting top, and an ergonomic armrest.

What you will love: This bed tray was designed with the laptop user in mind, with ergonomics and convenience in mind.

What you should consider: It’s one of the most expensive bed trays available, and it’s quite large.

Or buy: Sold by Amazon

Do you want to buy the best products at the best prices? Check out the daily deals from BestReviews.

Sign up here to receive the weekly BestReviews newsletter for helpful tips on new products and great deals.

April Blake writes for BestReviews. BestReviews has helped millions of consumers simplify their buying decisions, saving them time and money.

Copyright 2022 BestReviews, a Nexstar company. All rights reserved.

Here’s why a multimillion-dollar toy company is venturing into the metaverse Fri, 24 Jun 2022 02:41:00 +0000

When Jackson Aw was introduced to blockchain technology in 2018, he “didn’t get it at all.”

“Can someone make it even easier for me? For example, can you just tell me what I can get as a consumer?”

It was four years ago. Today, Aw, seems to have the answer to this question.

The 32-year-old Singaporean, who runs Mighty Jaxx – a multimillion-dollar toy company that produces collectibles and lifestyle products – has integrated blockchain into its products.

A blockchain is a decentralized digital ledger that records every transaction made. Nor can it be altered or modified retroactively.

CNBC Make It finds out why it “makes sense” for the collectibles empire to leverage blockchain capabilities and bet on the metaverse.

Unique certificates

Mighty Jaxx, which was founded in 2012, has partnered with some of the world’s biggest brands and visual artists, producing on-trend collectibles that incorporate pop culture and design.

Aw said the company has since sold millions of collectible toys to people in more than 80 countries.

Mighty Jaxx’s limited-edition collectibles can fetch up to $1,200 on its website, but in the secondary market they can fetch “five to ten times” more than their original value, Aw said.

Jackson Aw’s advice to young entrepreneurs? “Fear will always exist. But the question is, what do you think?”

Eli Lo

But there is a problem.

“When you want to sell the product, the number one question everywhere is ‘Is it genuine?'”

Aw added, “For collectibles, [sellers] do is they take pictures of the figurine and post it on Facebook groups, asking people to do an authenticity check.”

However, Aw was not satisfied with this method of authentication.

“Who is he talking about? Where is he from? So we thought, okay, this is what we need.”

Mighty Jaxx has designed a near-field communication chip, built into every toy. “With our app you can [scan the chip]register your ownership of the item,” said company founder Jackson Aw.

Eli Lo

Mighty Jaxx designed a near-field communication chip and built one into every toy. NFC technology enables short-range wireless communication between two devices.

“With our app you can [scan the chip]register your ownership of the item [to show] it’s a genuine Mighty Jaxx product,” Aw said.

Powered by blockchain, the platform issues and validates unique, tamper-proof certificates for each product. It also provides a digital fingerprint when ownership of an item changes.

…content and intellectual property are essential, because without any of this [visual] representation, that technology does nothing

Jackson Aw

Founder, Mighty Jaxx

“If Jay Chou or JJ Lin owned this figure before you, it’s definitely a lot more valuable than me,” Aw jokes. Jay Chou and JJ Lin are popular Mandarin pop singers.

Providing trusted authentication through blockchain technology is just “the beginning” for Mighty Jaxx.

A “phygital” advantage

With the market for non-fungible tokens seeing explosive growth in 2021, Aw said that was when there was “a culture shift as we knew it.”

“[Being] artists and creators in general… has always been more of a service job. But now it has changed. Now content and intellectual property are key, because without any of that [visual] representation, this technology does nothing,” Aw explained.

“Nothing speaks louder than visual form.”

NFTs are crypto-based digital assets that also function as collectibles – something Mighty Jaxx is no stranger to.

Therefore, it “makes sense” for Aw to venture into space, giving fans exclusive digital experiences with physical collectibles.

“When you buy our NFTs, you have access and the ability to buy the physical manifestation of it in that design. So only that group of people could buy that figure,” Aw said.

“Because they are the only ones who can do this and they can combine the two asset classes, it generates even more value for them.”

Collectors who purchase Mighty Jaxx’s NFTs gain exclusive access to purchase a physical manifestation of the same design, which “generates even more value for them,” Jackson Aw said.

Mighty Jaxx

Aw believes this is Mighty Jaxx’s “phygital” advantage over its competition – being able to offer both digital and physical assets.

“The fact that we create digital assets before we produce the physical toys…means we can get to market faster too,” he added.

“I can’t think of, you know, 10 other companies doing this around the world, just because the work that goes into creating a material or a [physical] to collect is naturally just a steeper learning curve.”

Metaverse Expansion

In 2021, Mighty Jaxx launched their first NFT trading card collection, featuring cats that look like Chinese food, dim sum.

“We threw 6,000 units, in…two seconds, they just ran out,” Aw said.

Mighty Jaxx got his big break from DC Comics when he signed a licensing partnership in 2015, allowing him to “restyle” creative IP.

Since then, he’s partnered with big-name brands to reach fandoms around the world, from Adidas, Hasbro and Nickelodeon, to Formula 1, Sesame Street and Netflix.

Aw says “there’s still a lot of work to do,” with plans to expand his IP collaborations into the metaverse as well.

The Metaverse is a collection of virtual worlds where people live, work, and play.

Mighty Jaxx’s first NFT trading card collection sold out in “2 seconds,” Jackson Aw said.

Mighty Jaxx

Research Bits: June 21 Tue, 21 Jun 2022 07:24:13 +0000

Side channel protection for edge AI

Researchers at the Massachusetts Institute of Technology have built a chip that can defend against power channel attacks targeting machine learning calculations in smartwatches, smartphones and tablets. Side-channel attacks involve observing one facet of the device’s operation, in this case power, to infer secrets.

“The goal of this project is to build an IC that does machine learning at the edge, so that it’s still low-power but can protect against those side-channel attacks so that we don’t lose confidentiality of these models,” said Anantha Chandrakasan, dean of the MIT School of Engineering and professor of electrical engineering and computer science at MIT. “People haven’t paid much attention to the security of these machine learning algorithms, and this proposed hardware effectively addresses that space.”

The chip is based on threshold calculation. Instead of running a neural network on real data, the data is first split into random components. The network operates on these random components individually, in random order, before accumulating the final result. In this way, the leak of information from the device is random every time.

However, the approach is more computationally expensive and requires more memory. To solve this problem, the researchers optimized the process by using a function that reduces the amount of multiplication the neural network needs to process the data. They also protect the neutral network itself by encrypting the model parameters. By grouping parameters into chunks before encrypting them, they provide more security while reducing the amount of memory needed on the chip.

“Using this special function, we can perform this operation skipping some steps with lesser impacts, which allows us to reduce overhead. We can reduce the cost, but it comes with other costs in terms of neural network accuracy. So we have to make a careful choice of the algorithm and the architectures we choose,” said Saurav Maji, a graduate student in MIT’s Department of Electrical Engineering and Computer Science.

The researchers compared their chip to a basic implementation without security hardware. In the baseline, they were able to retrieve hidden information after collecting around 1,000 power waveforms from the device. With the new hardware, even after collecting 2 million waveforms, they still couldn’t retrieve the data. The new chip also required 5.5 times more power and 1.6 times more silicon area than the reference.

“We are at the point where safety matters. We must be prepared to trade some power consumption to perform a safer calculation. It’s not a free lunch. Future research could focus on how to reduce the amount of overhead to make this calculation more secure,” Chandrakasan said.

They also tested the chip with biomedical signal data to make sure it would work in a real-life implementation. Next, they plan to apply the approach to electromagnetic side-channel attacks.

Silk PUF

Researchers from the Gwangju Institute of Science and Technology, Purdue University and Yonsei University have designed natural physical unclonable function (PUF) tags using silk. These tags were used to create a lensless, optical (light-based), wearable (LOP-PUF) PUF module.

“When a beam of light hits the disordered silk fibers of optimum density, it causes light to diffraction. The nanostructures of the individual microfibers enhance the light intensity contrast against the background. The light diffracted is then picked up by an image sensor. Since the pattern of micro-holes is created naturally, it is unique, resulting in a unique pattern of light,” said Young Min Song, a professor at the Institute of Gwangju Science and Technology.

The researchers optimized the distance between the silk-based PUF and the image sensor to achieve the desired intensity and contrast. The assembly also included a light-reflecting mirror and three tri-color LEDs, among other components. A cooling fan has also been used to reduce thermal noise. The team processed the captured light patterns and converted them into digital format.

“To our knowledge, this is the first PUF module designed from silk, a naturally abundant biomaterial. This means we don’t need to invest time in developing complicated security keys, nature has already done that for us,” Song said.

According to the team, the average time needed to “fake” authentication was around 5*1041 years, making the LOP-PUF module a virtually tamper-proof device. It also enabled digital encryption to prevent unauthorized access.

“The digital security device we designed is inexpensive, portable, environmentally friendly and requires no pre- or post-processing. It also does not require a coherent light source or a bulky lens system. The benefits of this system are multiple,” Song said.

Random numbers of skyrmions

Researchers at Brown University propose a way to exploit skyrmions to generate true random numbers. Skyrmions are tiny magnetic anomalies that result from the spin of electrons in certain two-dimensional materials.

“There has been a lot of research into the global dynamics of skyrmions, using their motions as a basis for making calculations,” said Gang Xiao, chairman of Brown’s physics department. “But in this work, we show that purely random fluctuations in the size of skyrmions can also be useful. In this case, we show that we can use these fluctuations to generate random numbers, potentially up to 10 million digits per second.

The team fabricated magnetic thin films using a technique that produced subtle defects in the material’s atomic lattice. When skyrmions form in the material, these defects, which the researchers call pinning centers, hold the skyrmions firmly in place rather than allowing them to move as they normally would.

When a skyrmion is held in place, its size fluctuates randomly. “Each skyrmion goes back and forth between a large diameter and a small diameter,” said Kang Wang, a postdoctoral fellow at Brown. “We can measure this fluctuation, which happens randomly, and use it to generate random numbers.”

The researchers said the skyrmion’s change in size is measured by the anomalous Hall effect, which is a voltage that propagates through the material. This voltage is sensitive to the perpendicular component of the spins of the electrons. As the size of the skyrmion changes, the voltage changes to an easily measurable extent. These random voltage changes can be used to produce a string of random numbers.

By optimizing the spacing of defects in the device, the researchers estimate they can produce up to 10 million random digits per second. “It gives us a new way to generate real random numbers, which could be useful for many applications,” Xiao said. “This work also gives us a new way to harness the power of skyrmions, by examining their local dynamics as well as their global movements.”

Winning medals, but at what cost? Sun, 19 Jun 2022 03:14:33 +0000

Here are some trivia for Indian sports fans. Before last month’s IBA World Championships in Istanbul, how many international matches has boxer Lovlina Borgohain competed in after her podium finish at the Tokyo Olympics last year?

Between his gold medal in the Japanese capital and last week’s national record at the Paavo Nurmi Games in Turku, Finland, how many events has Indian athletics poster Neeraj Chopra done? he participates ?

The answer to both is, wait, zero!

A small break is not out of place after such monumental accomplishments that leave athletes overwhelmed. Medals are the result of years of hard work and training. You want to live in the moment, soaking up the attention and relishing in the adulation. But going without a big competition for nearly a year, while most of your rivals are competing and keeping fit, doesn’t make a whole lot of sporting sense. Was it the athletes fault or did they have no choice but to stay away from the competition? Again, the answer to both is a resounding “yes”.

Shortly after Chopra crowned India’s greatest medal haul ever at the Olympics by throwing the javelin towards the gold medal, the entire country erupted in euphoria. From the Prime Minister to the head of a village panchayat in Haryana and officials from the Indian Olympic Association to heads of state bodies, everyone wanted a piece of the medalists, everyone was desperate to share the featured with the latest Indian superstars. Receptions and congratulations followed each other incessantly, and as a result the athletes fell ill or were exhausted.

Watch | ‘It was overwhelming’: Neeraj Chopra on making the legendary Milkha Singh’s wish come true

Chopra, who attended more than a dozen events in nine days, including open jeep parades in scorching heat, had to be hospitalized after falling ill during one of those functions. While the second wave of Covid-19 was still far from waning, he and other athletes were exposed to large crowds without masks. While he tested negative for Covid-19, the relentless stream of off-pitch events took a toll on his health. And with that, his plans to participate in back-to-back Diamond League meetings in Lausanne (August 26, 2021) and Paris (August 28, 2021) fell through due to a lack of training.

Chopra then flagged the issue in an interview with a national daily, saying, “Attention is indeed important, but there is a Diamond League at the end of the month. I had planned to participate, but my training completely stopped once I returned from the Olympics due to the constant number of functions.

“That’s why I feel like my fitness is not there now. I can’t compete properly. That’s why I have to skip the event. I had planned to compete in at least two or three events” , he said.

More than 10 months after Chopra raised the topic, Lovlina reiterated the downside of supported commendation features and programs in the immediacy of an international achievement.

Shortly after qualifying for the Commonwealth Games in Birmingham last week, the boxer spoke at length about how attending events, where she was recognized and rewarded for her bronze medal with barely a break to resting or training, affected her preparations, ultimately forcing her to be undercooked at the boxing world championships held recently

It was the Assam boxer’s first international encounter after the Tokyo Games and her campaign in the 70kg category ended in the pre-quarter-finals.

“The main thing was that at the World Championship I was not so strong mentally,” Lovlina stressed. “I was not able to concentrate properly. I worked on it.

Read | It’s no shame. Period!

“My goal was to win gold in Tokyo, but I couldn’t. After that, in my head, I kept thinking, “I have to train and pass the next competition”. But that didn’t happen. After Tokyo, people started expecting a lot. I also had to attend several receptions and you can’t say no because they will think “after winning a medal she developed an ego”.

Rewards and rewards are vital for athletes, but they should not be extended to the point where athletes begin to dread them.

Training without distraction is what gets them to this point and if that’s sacrificed on the altar of kudos, it would be losing sight of the main goal. Arguably, athletes can put their foot down and say enough is enough, but how many will risk hurting the giant egos of the powers that be?

“There are times when you can’t do anything and you have to miss your training. It affects us. A player needs to have space to focus on the game. I didn’t think any of this would affect my performance, but somehow it did,” added Lovlina. It’s not just ministers and federation officials that athletes have to worry about; they must also respect the commitments of their respective sponsors, whether it concerns media or meeting and welcoming fans. This requires setting aside considerable time for your routine and traveling to various cities which can be physically taxing.

As professionals, athletes too need to be aware of what is in their best interest. By his own admission, Chopra, after missing a few events due to illness, slacked off a bit. He had no control over his diet and his training took a back seat. Instead of adding yards to his throws, he added mass to his once chiseled frame. That meant more time away from the competition.

“When I came back from the Olympics, I didn’t put any restrictions on my diet,” Chopra admitted after returning to training in December in the United States. “I had been in control of my eating habits for a very long time, thinking that I had to hold back until I succeeded in Tokyo. After the Olympics, I gained 12-13 kilos. I lost five kilos and I Reached my normal off-season weight.It’s been about 20 days since resuming training and I’ve reduced a lot.

“It was really difficult at the beginning. My body was hurting and I had to put in extra effort for everything. I was physically exhausted earlier than usual, but I pushed myself mentally.

Of course, India as a sporting nation is a work in progress and it will take some time to come out of this feudal mindset. But top athletes who openly express their concerns might just speed up this process.

Global RPA and Hyperautomation Market Size to Grow Fri, 17 Jun 2022 08:12:06 +0000

New York, June 17, 2022 (GLOBE NEWSWIRE) — announces the release of the report “RPA and Hyperautomation Market by Component, Business Function, Deployment Mode, Vertical and Region – Global Forecast to 2027” – https://www.
For a long time, leaders were unprepared for an overnight transformation to 100% digital operations. Remote work, e-commerce, security, supply chain, and business processes and software were all vulnerable to overwhelming expectations, bottlenecks, and points of failure across the organization. Business continuity and stability has suddenly become everyone’s top priority.

BFSI segment is expected to have the largest market size during the forecast period
In the BFSI industry, multiple systems are connected to each other through interfaces to allow the flow of transaction-related data. Automation solutions control and monitor these interfaces to ensure seamless transaction execution and resolve workflow bottlenecks.

These solutions improve the accuracy and efficiency of various processes and facilitate regulatory and compliance reporting by bringing together data from multiple systems and performing validation checks to prepare information for detailed analysis. Most banks are increasingly deploying hyperautomation solutions to improve productivity, improve cost savings, and improve customer experience.

Among the regions, APAC holds the highest CAGR during the forecast period
The Asia-Pacific region market is expected to grow at the highest CAGR during the forecast period. The RPA and hyperautomation market in the Asia-Pacific region includes China, Japan, India, and other countries in the region.

China, Japan, and India are among the key driving countries for the RPA and hyperautomation market in APAC.

The adoption of artificial intelligence technology by different verticals, such as BFSI, manufacturing, and retail, is expected to contribute to the strong growth of the RPA and hyperautomation market. Rapid economic development, globalization, digitalization, and increased adoption of cloud-based technologies are expected to drive the growth of the RPA and hyperautomation market in the Asia-Pacific region.

Distribution of primaries
In-depth interviews were conducted with CEOs, chief innovation and technology officers, system integrators, and executives from various key organizations operating in the call center AI market.
• By company: Level I: 35%, Level II: 45% and Level III: 20%
• By designation: C-level executives: 35%, D-level executives: 40% and others: 25%
• By region: North America: 45%, Asia-Pacific: 30%, Europe: 20% and Rest of the world: 5%
The report includes the study of key players offering the RPA and Hyperautomation market. Major vendors covered are IBM (US), Microsoft (US), SAP (Germany), Alteryx (US), Appian (US), Juniper Networks (US), NICE (Israel) , Zendesk (US), Pegasystems (US). ), Automation Anywhere (US), UiPath (US), ProcessMaker (US), SolveXia (Australia), PagerDuty (US), Celonis (US), Blue Prism (UK) , Laserfiche (US), akaBot (Vietnam), HelpSystems (US), Decisions (US), Datamatics (US), Quale Infotech (India), Laiye (China), Rocketbot (Chile), ElectroNeek (US), (US), AutomationEdge (US), (US), Turbotic (Sweden), Simple Fractal (US) and G1ANT (England).

Research coverage
The research study for the RPA and Hyperautomation Market involved numerous secondary sources, directories, and several journals, including the Journal of Intelligent Learning Systems and Applications, the International Journal of Advanced Science and Technology, and the International Research Journal of Engineering and Technology (IRJET). Primary sources were primarily industry experts from core and related industries, preferred RPA and hyperautomation solution providers, third-party service providers, consulting service providers, verticals, and other commercial enterprises . In-depth interviews were conducted with various key respondents, including key industry players and subject matter experts, to obtain and verify critical qualitative and quantitative information and to assess the market outlook.

Key Benefits of Purchasing the Report
The report would provide market leaders/new entrants in this market with information on the closest approximations of revenue figures for the overall RPA and Hyperautomation market and its sub-segments. It would help stakeholders understand the competitive landscape and acquire more information to better position their business and plan appropriate go-to-market strategies.

It also helps stakeholders understand the pulse of the market and provides them with insights on key market drivers, restraints, challenges, and opportunities.
Read the full report:

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		Could floating solar panels be the new normal?
		Wed, 15 Jun 2022 08:04:23 +0000


Floating solar panels or floating photovoltaic refer to solar panels designed for bodies of water; it works the same way as the regular solar panels we see on rooftops, converting light into electricity. With the emergence of floating solar farms, one may wonder what is the point of putting solar panels on the water. Here, we explore the relative advantages and disadvantages of floating solar panels versus conventional terrestrial panels.

Currently, the the largest floating solar farm in the world is located in Dezhou, Shandong, China, generating 320 megawatts (MW) per hour. But several other countries have begun to launch their own plans to dethrone China’s current leadership status. This includes Indiawhich is building a 600 MW floating solar farm at the Omkareshwar Dam on the Narmada River, as well as South Korea, which has built a floating solar farm with a capacity of 1,200 MW in North Jeolla province, which is equivalent to about 0.9% of the total power generation capacity of the whole country. It is expected to be in commercial operation by the end of 2022.

Floating solar panels have higher efficiency

Compared to the long history of solar energy, the concept of floating solar only emerged in the late 2000s and is rapidly being adopted. In 2021Floating solar across the world has generated around 1,600 MW of electricity, but this number is estimated to reach 4,800 MW by 2026, with a compound annual growth rate of 33.7%.

One of the main reasons why this technology is favored by nations is its relatively high efficiency compared to ordinary photovoltaics. Floating solar can go up to 15% more efficient than terrestrial solar, according to the Environmental and Energy Study Institute, due to the cooling effect of water. Solar panels, like other electrical equipment, work most efficiently when kept cold.

The ideal temperature for a solar panel is less than or equal to 25C, and it will experience a decline in productivity when its temperature is higher 25C. Based on the model starting at 25C, a solar panel loses about 0.3% to 0.5% efficiency for every 1C increase in temperature. The percentage decrease for each degree may not seem high at first, but since most solar panels can get much hotter than 25°C, reaching up to 40°C, 50°C or even 60°C in this era of climate change, the cumulative effect becomes much larger.

Although the ambient temperature in summer in most countries is around this range, the temperature of the solar panel is much higher than its ambient temperature because its main function is to absorb heat energy from the sun. Ironically, despite solar technology’s purpose in mitigating global warming, it dramatically increases the temperature in urban areas by trapping heat on rooftops.

Today, the efficiency, which refers to the share of energy in the form of sunlight that can be converted into electricity, of most solar panels ranges from approximately 15% to 20%. If a solar panel that can operate at 20% efficiency reaches a temperature of 45 C or 55 C, its efficiency falls in the range of 18% to 18.8% or in the range of 17% to 18.2% respectively .

This is where the concept of floating solar comes in. Seeing that terrestrial solar panels are not performing to their full potential, scientists came up with the idea of ​​using water as a coolant to keep the temperature of solar panels down. , preventing energy loss due to high temperature.

You May Also Like: 12 Facts About Solar Energy You May Not Know

Floating solar power uses less land

One of the largest onshore solar parks in the world is the Bhadla Solar Park located in Jodhpur, Rajasthan, India. It has a production capacity of 2,245 MW per hour. Yet, in order to capture so much energy, this solar farm occupies over 14,000 acres of land to do so. Not all countries are as big as India and have so much land available to build multiple onshore solar farms. Floating solar, on the other hand, does not require rare terrestrial solar panel installations. Floating solar can be implemented in many types of water bodies, from oceans to lakes and reservoirs, where the opportunity cost of building solar panels is relatively low because they are mostly inactive and n only use fractions of space – and do not affect leisure. activities such as fishing.

Cost of floating vs land

If we compare the two, all the disadvantages of floating solar panels such as the intermittency of solar access or the pollution (and greenhouse gases) from the extraction and production of the materials used to produce them, can also be applied to their terrestrial counterparts while the advantages of floating solar panels are not inversely replaceable; the former is essentially the most evolved version of the latter. However, if we really want to nitpick, the cost of floating solar is more expensive than that of terrestrial solar. Estimates suggest that the installation cost of floating solar panels is about 10-15% higher than terrestrial panels, considering the additional cost required to manufacture the floats. But in terms of the cost of operation and maintenance, it is surprisingly close between the two. Although activities such as accessing floating panels away from shore or preventative maintenance of anchors and mooring lines require additional costs, these additional costs are offset by the elimination of fence maintenance costs. as well as the lack of vegetation, which is often applied in terrestrial solar to keep the panels cold.

The future of floating solar

Due to its relative infancy, current floating solar technology requires a one-time installation cost that is more expensive. Nevertheless, compared to its long-term effects on preventing energy leakage up to 15%, at least during the life of solar panels of 25 years, floating solar is actually more cost effective and one can make argue that its benefits outweigh terrestrial solar. Governments should consider adding floating solar technology to the energy portfolio and part of renewable energy transition strategies.

Watch what’s happening tomorrow during the TC sessions: climate Mon, 13 Jun 2022 15:00:19 +0000

Tomorrow, June 14, is the big day for anyone interested in the latest technologies designed to combat climate change. More than 1,000 people will gather to TC sessions: climate and world final of the Extreme Tech Challenge 2022 in Berkeley, CA to hear, learn, and engage with leading climate scientists, founders, VCs, entrepreneurs, philanthropists, and other visionaries. We look forward to seeing you there!

Buy now and save: Tickets cost more at the door. Buy your pass now and save $100. Bonus content: Your pass also includes access to the June 16 online event.

It’s a full day of content and connection, and we want to highlight just five of the many presentations happening throughout the day.

1. The climate crisis is real — the solutions should be too: It is fitting that the first panel of the first sessions of TC: Climate begins with climate science. Establishing a common understanding of the global crisis and what the future holds if we do not act decisively – and with due haste – is essential. Dr. Williman Collins, an internationally renowned expert in climate modeling and climate change science, and Dr. Kari Nadeau, a world-renowned environmental health expert, set the stage for a discussion on pragmatic and realistic ways to mitigating climate change through technology.

2. Bill Gates explains how to deploy billions in clean technologies: Gates has made the climate emergency a key part of his work in recent years. In 2015 he announced a fund dedicated to bringing the world to net zero emissions by 2050, and in the same year he founded Breakthrough Energy – a network of investment vehicles, nonprofits and philanthropic programs committed to achieving this goal. We’ll hear from Gates about what he thinks are the top priorities for investing in climate technologies.

3. Powering the future with transformative technology: This panel of folks from Extreme Tech Challenge – and straight from the “it takes a global village” file – jumps into game-changing technological innovations that are transforming industries to build a radically better world. How can business, government, philanthropy and the startup community come together to create a better future? Hear from seasoned investors and industry veterans on how technology can not only shape the future, but also where the biggest opportunities lie.

4. Kitchen suite: The direct link between farmed animals and climate change inspired Pat Brown, founder, former CEO and now visionary director at Impossible Foods, to develop better plant-based meat. So far, his vision has been a resounding success, with Impossible reaching a valuation of $9.5 billion last year. An innovative approach to its product development has propelled the company into restaurants and homes around the world. Watch Brown as he discusses the present — and future — of fake meat.

5. The road to zero emissions: Despite increasingly stringent regulations in some states and the rise of electric bicycles, scooters, mopeds, buses and cars, the vast majority of vehicles on the roads today still emit emissions from tailpipes, and current technology for building EV batteries is not zero. – respectful of emissions. Wayne Ting, CEO of Lime, and Carol Browner, former director of the White House Office of Energy Policy and Climate Change and EPA administrator, will discuss the challenges that remain and the role that innovation, policy and investment can play a part in greening transport.

But wait, check the event agenda because there is so much more – young shoots exhibiting their climate technology on the exhibition floor, the Extreme Tech Challenge 2022 World Finalswith two rounds of pitches before declaring the winner and, as always, world-class networking.

TC Sessions: Climate 2022 will take place tomorrow, June 14 in Berkeley, CA (with an online day on June 16). Buy your pass today and avoid higher prices at the door tomorrow. We will be there to welcome you! ( function () { var func = function () { var iframe = document. () { iframe.contentWindow.postMessage( { ‘msg_type’: ‘poll_size’, ‘frame_id ‘: ‘wpcom-iframe-2630e5f45a7134273745f74bbfdcbf94’ }, “” ); } } // Autosize iframe var funcSizeResponse = function( e ) { var origin = document.createElement( ‘ a’); origin.href = e.origin; // Check the origin of the message if ( ‘’ !== ) return; // Check that the message is in an expected format if ( ‘ object’ !== typeof || undefined === ) return; switch ( ) { case ‘poll_size:response’ : var iframe = document.getElementById( _request.frame_id ); if ( iframe && ” === iframe.width ) iframe.width = ‘100%’; if ( iframe && ” === iframe.height ) iframe.height = parseInt( height ); r return; default: return ; } } if ( ‘function’ === ty peof window.addEventListener ) { window.addEventListener( ‘message’, funcSizeResponse, false ); } else if ( ‘function’ === typeof window.attachEvent ) { window.attachEvent( ‘onmessage’, funcSizeResponse ); } } if (document. readyState === ‘complete’) { func. apply(); /* infinite scroll compatible */ } else if ( document.addEventListener ) { document.addEventListener( ‘DOMContentLoaded’, func, false ); } else if ( document.attachEvent ) { document.attachEvent( ‘onreadystatechange’, func ); } } )();

Shotgun Metagenomics with HiFi Playbacks: Now More Affordable Tue, 07 Jun 2022 20:38:04 +0000

Unlocking the secrets of complex communities and microbiomes represents one of the most exciting frontiers in microbiology, with the potential to revolutionize our understanding of human health, food production and environmental preservation. To lay the groundwork for such breakthroughs, it is essential to fully capture and profile all the genetic information present in a complex microbiome or community; and shotgun metagenomic methods are essential for obtaining such information.

In search of the best shotgun metagenomic data, PacBio HiFi sequencing continues to set the standard for quality and completeness, thanks to exciting innovations in data analysis tools. These new pipelines, together with the powerful combination of high accuracy and long read-time of HiFi data, provide more accurate profiling information than any other technology on the market. Plus, HiFi data returns more assembled single-contig circular metagenome (MAG) genomes than ever before, giving you the power to discover the hidden functions of the microbial ecosystem and confidently capture the richness and diversity of species.

In one look

  • HiFi shotgun metagenomic sequencing generates datasets consisting of individual reads spanning up to 8 contiguous genes, allowing you to precisely profile the function and taxonomy of a community, all at once.
  • Taxonomic and functional profiling of HiFi metagenomes can now be performed at nearly one-third the cost† without compromising accuracyusing information from subsampling experiments.
  • Assembly-focused HiFi metagenomic studies can return tens to hundreds of high-quality (HQ) MAGs, with up to 33% of those MAGs being a single contig, allowing you to predict genes and make taxonomic annotations with authority.

Get stunning quality HiFi metagenomic profiling data at lower cost

Profile more affordably using just 0.5GB of HiFi data to get the same state-of-the-art species and diversity information that can be found with 88GB, or probably more.

The proof is in the research: In order to help microbiologists obtain the most cost-effective information possible from HiFi data, we performed a series of subsampling studies. Each analysis was performed to find the minimum depth needed to obtain highly accurate community profiles as well as to determine recovery rates for MAG and single-contig MAG.

To begin, we sequenced the ZymoBIOMICS fecal reference with TruMatrix technology, which is a pooled highly complex human gut microbiome sample that is extremely useful for benchmarking and reference standards. We sequenced this sample using 4 SMRT 8M cells, then took the dataset and downsampled it incrementally to coverage equivalent to a multiplexed sequencing sequence of 96 on a single SMRT cell. 8M (96-plex). The study captured a total range of 88 to 0.3 gigabases (Gb) of data. Each level of data was then run through PacBio’s taxonomic profiling workflow.

HiFi data captures abundance at shallow depths
Figure 1.) The taxonomic results of subsampling with the optimized filter in the PacBio metagenomic profiling pipeline (described in this webinar). The number at the top of each bar is the total number of species detected at each level of data and the colors represent relative abundances.

The results of this workflow showed that the information obtained from 4 SMRT 8M cells up to 48-plex is largely consistent, with not only similar numbers of species recovered (Fig. 1), but the profiles of relative abundance also being nearly identical (Figure 2). This indicates that the same level of taxonomic profiling information can be obtained with 0.5 GB at the 48-plex level as 88 GB, providing microbiome researchers with an even more affordable entry point into the world of HiFi metagenomics.

Species richness information
Figure 2) Relative abundance and taxonomic assignments for the ZymoBIOMICS TruMatrix fecal reference, subsampled to progressively lesser sequencing depth starting at 4 SMRT cells and ending at 96-plex.

Listen to Dan Portik Ph.D. (@DPortik) Senior Scientist, Bioinformatics at PacBio, discusses these findings in our recent metagenomics webinar, on demand now.

Capture species in exquisite detail with more HQ-MAG than ever before

Achieve optimal cost-benefit ratios from one sample per 8M SMRT cell for assembly-focused metagenomic HiFi sequencing. Projects seeking deeper insight can increase sequencing depth with multiple 8M SMRT cells to capture rare microbes in stunning detail.

How do we know: The second half of our subsampling study was devoted to establishing guidelines for metagenome assembled genome (MAG) studies. To assess the effects of sequencing depth on MAG assembly, we took the ZymoBIOMICS TruMatrix 4 SMRT Cell 8M gut microbiome dataset and progressively downsampled it to a depth of 8 plexes to examine the effects on assembly and recovery at each level. We know that assembly is much more sensitive to sequencing depth and that there is a very predictable relationship between sequencing depth and outcome. However, in our pipeline, depth has a different impact on HQ-MAG recovery and single-contig MAG recovery.

HQ-MAG recovery
Figure 3.) A comparison of the number of assembled genomes per metagenome (MAG) retrieved versus depth of sequencing. The green line shows the total number of high-quality (HQ) MAGs returned and the purple line shows the number of single-contig MAGs retrieved at a given data level.

The results of our workflow show that from 8-plexes there is a logarithmic relationship between total MAG recovery and depth (green line in Fig. 3), with rapid gains down to a single cell SMRT 8M. From here, recovery efficiency is somewhat reduced as sequencing depth increases, but HQ-MAGs are still returned in large numbers, with the deeper sequencing yielding what are almost certainly deeper species rare. For recovery of single-contig MAGs (Fig. 3, purple line), there is a distinct linear relationship between recovery and depth with 4 SMRT Cell 8M yielding 199 total HQ-MAGs, of which 72 are single-contig. Even at 8-plex depth, 9 HQ-MAGs were recovered and 2 were single contigs. At 4-plex, 34 HQ-MAGs were generated with 9 being single-contig. These results clearly indicate that HiFi shotgun metagenomic sequencing can provide many extremely detailed genome assemblies that would be difficult to obtain with alternative sequencing technologies.

Listen to Dan Portik Ph.D. (@DPortik) Senior Scientist, Bioinformatics at PacBio, discusses these findings in our recent metagenomics webinar, on demand now.

Observe the microbial world with stunning clarity

HiFi metagenomics gives microbiome researchers the power to accurately profile function and taxonomy of a community with greater profitability than ever before. At the same time, the incredible length and accuracy of HiFi readings allow investigators to take advantage of the impressive HQ-MAG recovery to predict genes and make taxonomic annotations with greater confidence. Together, these advantages make HiFi sequencing the premier sequencing solution for ambitious projects aiming for breakthrough discoveries.

Want more?

Check out the recap of our recent metagenomics webinar
Watch our HiFi metagenomics talk, available on demand now
Discover our HiFi solutions for metagenomics
Access HiFi Metagenomics Datasets
Try the PacBio HiFi metagenomics pipeline

Compared to the previous recommendation of 8 samples multiplexed by SMRT Cell 8M. The 48-plex shotgun metagenome profiling recommendation is for community standard taxonomic and functional profiling using optimized PacBio github pipelines. If you are interested in more in-depth functional profiling analysis, you can target less multiplexed samples on a single 8M SMRT cell.

The Fascinating History of Steinberger Guitars | Mon, 06 Jun 2022 08:00:14 +0000

Established in 1979, Steinberger introduced a new look and functionality to the music industry. While the headless design of its guitars is rightly the company’s best-known and most striking feature, its innovative ideas didn’t stop there.

Founder Ned Steinberger is the son of Nobel Prize-winning particle physicist Jack Steinberger. In the 1970s, Ned was not a musician, he was a furniture maker, who still holds several patents for chair designs. His first foray into musical instrument building came with the Spector NS2 bass guitar, designed alongside luthier Stuart Spector. It wasn’t until 1976 that Ned started tinkering with his own unorthodox designs.

Between 1979 and 1986, Ned brought these creations to life. His guitars featured a unique minimalist shape and, at first, were constructed entirely from a synthetic fusion of fiberglass and carbon fiber, known as Steinberger Blend. Most guitars are made of wood, a biological agent subject to variation, even within the same species of tree.

Ned Steinberg

This variation is something we appreciate and as guitar builders we can use it to our advantage to fine-tune the tonal properties of an instrument. Steinberger’s blend of carbon fiber and graphite, however, offered more consistency and durability, as it was not susceptible to the ebb and flow that accompanies changes in humidity and temperature levels. Later, however, Ned’s designs would also begin to incorporate wood.

Steinberger has made five models over the years – the P, S, M, K and Q series – and each would typically make up a range of guitars and bass guitars. And, of course, most of them were headless. The S-series instruments, however, had headstocks. But it was Steinberger’s rarest, with only around 300 made.

Steinberg GL2
Steinberg GL2

Steinberger did not invent the headless guitar. Les Paul made one in the 1940s, using a similar design in which the strings are anchored at the nut and tuned at the bridge. The Les Paul guitar, however, was aluminum. He could never get it to stay in tune and intonate properly, so he never marketed it. Decades later, Steinberger remedied this problem with its “straight-pull” tuning mechanism, as well as its calibrated double-ball strings, which did not need to be cut.

Of the dozens of guitar design patents held by Ned Steinberger, most focus on improving tuning stability. In 1984, Steinberger developed the TransTrem, a unique tremolo bridge. On a standard vibrato, the strings are stretched at different rates, but the TransTrem allows whole chords to be raised and lowered in pitch together. The TransTrem can also be locked, allowing it to essentially function as a capo as well. The downside is that the bridge requires these calibrated double-bullet strings – which are only made by a few companies, including D’Addario, La Bella and Steinberger himself. TransTrem’s idea was later replicated by other companies, with varying success. The Washburn Wonderbar, for example, was developed to work in the same way but uses standard chains and has no locking function. More recently, the EverTune bridge has been designed to work similarly.

Steinberger L2
Steinberger L2

These ideas were patented under the Steinberger banner, but the patent on the TransTrem has since expired, and Steinberger was purchased by Gibson in 1986. The sale to Gibson allowed Ned to focus on the pattern instruments, rather than their commercial transactions and production. Ned remained involved in the production of Steinberger guitars under Gibson ownership, and even helped design the Synapse line – Gibson-produced, wood-built guitars and basses.

Eventually, Ned left Gibson and Steinberger behind to design and build his own instruments. But since Gibson owned the company label—his surname—Ned was no longer able to make guitars under his own designation. So in 1990 he started making instruments under the NS Design banner – violins, violas, cellos, double basses, double basses, bass guitars, nothing was off limits. NS Design still produces instruments today, but not the headless guitars that Ned is most famous for.

Steinberger L2
Steinberger L2

Meanwhile, Gibson stopped production of Steinberger guitars in 1998. It resumed making them later but did not follow the original design. Seeking a more cost-effective way to make these unusual instruments, Gibson instead began manufacturing the wooden guitars in South Korea.

Steinberger guitars and their advances in the instrument have developed a cult following and have been used by artists such as Mark Knopfler, David Bowie, Eddie Van Halen, Jerry Garcia, Lou Reed, David Gilmour, Sting, Geddy Lee and Allan Holdsworth. The first three prototypes of the L2 bass were sold to John Entwistle, Tony Levin and Andy West of The Dregs. Although these instruments are no longer in production, Steinberger guitars hold a creative legacy that still resonates to this day.

To learn more about current Steinberger guitar models, visit Check out NS Designs at